In April 2021, Esposito publicly shared on social media that she identifies as genderfluid and prefers she/they pronouns. Then in June 2021, Esposito revealed on Twitter that she had tied the knot with Katy Nishimoto, who works as an editor for Dial Press.

Katy Nishimoto supported Cameron Esposito

Katy has autoimmune disease which made it difficult for her to move around with ease, affecting her energy levels, strength, and balance. To help her navigate better and maintain her independence, she decided to get some walking sticks which have proven to be a great support in helping her move around more comfortably.

Cameron Esposito was previously married to River Butcher


Cameron openly identifies as a lesbian. She was married to another comedian, River Butcher, from 2015 to 2018. Together, they worked on various projects such as the Put Your Hands Together show, the podcast Wham! Bam! Pow!, and the TV show Take My Wife.

In Cameron's essay on Refinery29, she talked about her close relationship with Katy, suggesting they have been friends for some time. She mentioned how Katy was there for her during her divorce with River, showing support and care. Cameron also expressed concern for Katy's health during the COVID-19 pandemic due to her autoimmune disease.

Katy Nishimoto and Cameron Esposito

The comedian felt that being physically distant from their new partner at the beginning of their relationship was beneficial. This allowed them the necessary time and space to focus on going through a divorce and taking care of themselves without relying too heavily on their new partner for support.

On June 4, 2024, Cameron opened up about her struggles with a post-surgical infection in an emotional Instagram post with her wife. She mentioned having to make multiple visits to the hospital within a month. In a previous post on June 7, 2023, she delved into her diagnosis of Bipolar Disorder and shared that she had been taking brain medication since December 2022, acknowledging the side effects that come with it.